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C F S
- Information International Brain
Scans and CFS/ FM
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Brain Dysfunction – Newest Evidence
Evidence for reduced brain
cortical blood flow in CFS, yoshiuchi.etal.06.txt,
yoshiuchi.etal06.txt, yoshiuchi.etal06.pdf. Altered cerebral oxygenation
and blood volume may contribute to the reduced exercise load in CFS, supports
the contention that CFS, in part, is mediated centrally, neary.etal08.txt, neary.etal08.pdf.
Ventricular cerebrospinal fluid
lactate is increased in CFS compared with generalized anxiety disorder: an in
vivo 3.0 T (1)H MRS imaging
study, mathew.etal08.txt,
mathew.etal.08.txt, mathew.etal08.pdf. Clinical
correlate of brain SPECT perfusion abnormalities in FM, guedj.etal08.txt. The symptoms seen with brain damage are listed (for
comparison with CFS/ FM symptoms), braininjury.symptoms04.txt. Positron Emission Tomography (PET)
Although abnormalities in
FDG-PET were detectable in approximately half the CFS patients, no specific
pattern for CFS could be identified,
Siessmeier et al., 2003, Siessmeier et al., 2003 (pdf). The density of serotonin
transporters (5-HTTs) in the brain, as determined by using a radiotracer, [C](+)McN5652,
was significantly reduced in the rostral subdivision of the anterior
cingulate in CFS as compared with that in normal volunteers, yamamoto.etal04.txt, yamamoto.etal04.pdf.
‘There was a widespread reduction in 5-HT(1A) receptor binding
potential in CFS relative to control subjects. This was particularly marked
in the hippocampus bilaterally, where a 23% reduction was observed', cleare.etal05.txt, cleare.etal05.pdf. Single-photon Emission Computed Tomography (SPECT)
British studies found
abnormalities in ME/CFS with SPECT, Richardson & Costa, 1998. Dr.
Buchwald's team studied twins with and without CFS and found no difference
using SPECT,
Lewis et al., 2001. A comprehensive SPECT study of CFS and depressive
patients found both similarities and differences, Machale et al., 2000, Machale et al., 2000 (pdf). An Australian SPECT-study
of regional cerebral blood flow in FM patients found a deficiency locally in
the thalamic area, Kwiatek et al., 2000.
With CFS patients, these researchers found hypofusion in local brain areas, Casse et al., 2001. Reduced rCBF at
cortical regions in FM patients was demonstrated, chen.etal07.txt. Researchers from Texas, US have provided interesting
preliminary evidence for a deficit in cerebral perfusion in CFS by using
SPECT, Schmaling et al., 2003 (short), Schmaling et al., 2003 (paper), Schmaling et al., 2003 (pdf). Patients with FM were evaluated and the effects of
amitriptyline treatment and consequent clinical recovery on cerebral blood
flow changes registred by SPECT, adiguzel.etal04.txt.
(99m)Tc-ECD brain perfusion SPECT in
hyperalgesic FM, guedj.etal06.txt. Magnetic Resonance Imaging (MRI)
MRI scanning results correlate with physical
functioning in CFS, Cook
et al., 2001. These researchers found increased volume
of the ventricular system in CFS by MRI, Lange et al., 2001, Lange et al., 2001 (pdf). Functional (f)MRI combined with skill testing was
used to demonstrate neurological brain defects in CFS patients, delange.etal04.txt, delange.etal04.pdf.
These researchers have also demonstrated reduced global gray matter volume in
CFS patients, delange.etal05.txt,
delange.etal05.pdf. Reduced responsiveness is an
essential feature of chronic fatigue syndrome: a fMRI study, tanaka.etal06.txt. Enhanced neural mechanisms of temporal summation of "second
pain" (TSSP) in FM are reflected at all pain related brain areas,
including posterior thalamus, staud.etal08.txt. Mechanisms underlying fatigue: a voxel-based
morphometric study of CFS, patients with CFS had reduced grey-matter volume
in the bilateral prefrontal cortex, okada.etal04.txt,
okada.etal04.pdf. Also in FM, reduced grey-matter could be seen with MR-imaging and voxel-based
morphometry, schmidt-wilcke.etal07.txt. (f)MRI correlates of mental fatigue induced by cognition
among CFS patients and controls, cook.etal07.txt,
cook.etal07.pdf. Feeding patients tryptophan
before the Stroop task does not increase their cognitive skills measured by
(f)MRI, morgan.etal06.txt Pain can be visualized using fMRI, derbyshire.etal04.txt. Probing the Working Memory System in CFS: A
Functional MRI Study Using the n-Back Task, caseras.etal06.txt,
caseras.etal06.pdf. Proton Magnetic Resonance Spectroscopy (MRS)
Reduced concentration of
N-acetylaspartate in the right hippocampus of CFS patients, Brooks et al., 2000,. Increase
in choline in the occipital cortex, Puri
et al., 2002. Dr. Chaudhuri, also found increased choline
resonance in CFS brain basal ganglia using H MRS, Chaudhuri et al., 2003,
Chaudhuri et al., 2003 (pdf). A comprehensive review of MRS
in neuropsychiatric disorders, cox.puri04.txt, cox.puri04.pdf. Proton neurospectroscopy and 31-P
neurospectroscopy can yield
information relating to the metabolism of cerebral membrane
phospholipids, puri06.txt, puri06.pdf
and puri.etal06.txt, puri.etal06.pdf.
Proton MR spectroscopy in the evaluation of cerebral
metabolism in patients with FM: Comparison with healthy controls and
correlation with symptom severity, petrou.etal08.txt. Hippocampus
dysfunction shown in FM with single-voxel MRS, emad.etal08.txt.
Using single voxel proton magnetic resonance spectroscopy an abnormality in hippocampal
brain metabolites in female FM patients with no psychiatric comorbidity, wood.etal08.txt. Low-resolution electromagnetic brain tomography
(LORETA) of monozygotic twins discordant for CFS, sherlin.etal06.txt
sherlin.etal06.pdf. Central Motor Conduction
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