In vivo MR spectroscopy in diagnosis and research of neuropsychiatric
disorders.

Prostaglandins Leukot Essent Fatty Acids. 2004 Apr;70(4):357-60.

Cox IJ [*], Puri BK.

Faculty of Medicine, Imaging Sciences Department, Imperial College
London, Division of Clinical Sciences, Robert Steiner Magnetic Resonance
Unit, Hammersmith Campus, Du Cane Road, London W12 0HS, UK.

[*] Corresponding author. Tel.: +44-20-8383-3298; fax: +44-20-8383-3038
E-Mail: mailto:j.cox@imperial.ac.uk

Accepted 18 December 2003.  Available online 18 March 2004.

NLM Citation: PMID: 15041027


Magnetic resonance spectroscopy is one of the most important tools for
quantitative analysis of chemical composition and structure, and this
non-invasive technique is now being applied in vivo to study biochemical
processes in those neuropsychiatric disorders that are part of the
phospholipid spectrum.

Interpretation of a clinical magnetic resonance spectrum can provide
information about membrane phospholipid turnover, cellular energetics,
neuronal function, selected neurotransmitter activity and intracellular
pH. Cerebral proton and phosphorus magnetic resonance spectroscopy
findings are summarized in relation to schizophrenia, dyslexia and
chronic fatigue syndrome.

Copyright © 2004 Elsevier Ltd. All rights reserved.