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C F S
- Information International Genetics in
CFS & FM
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Newest Research
Genetic profiles in
severe FM and CFS, garcia-fructuoso.etal07.txt.
Identification of
marker genes for differential diagnosis of CFS, saiki.etal.08.txt,
saiki.etal08.txt. Seven
genomic subtypes of CFS/ME: a detailed analysis of gene networks and clinical
phenotypes, kerr.etal07.txt, kerr.etal07.pdf. Gene expression subtypes in
patients with CFS/ME, kerr.etal08.txt, kerr.etal.08.txt, kerr.etal08.ref.txt.
kerr.etal08.tab1.txt, kerr.etal08.tab2.txt, kerr.etal08.tab3.txt, kerr.etal08.tab4.txt, kerr.etal08.pdf. Gene profiling of patients with CFS/ME, kerr08.txt Bayesian
biomarker identification based on marker-expression proteomics
data in
CFS, bhattacharjee.etal08.pdf. Integrated
weighted gene co-expression network analysis with an application to CFS, presson.etal08.txt. Genetic evaluation
of the serotonergic system in CFS, smith.etal08.txt, smith.etal08.pdf. Lower frequency of
IL-17F sequence variant (His161Arg) in CFS,
metzger.etal08.txt, metzger.etal.08.txt,
metzger.etal08.pdf. Family History of CFS
Family history implicate a
genetic basis for CFS,
Walsh et al., 2001. Symptom analysis of australian twins with
somatic symptoms,
Gillespie et al., 2000, and the occurrence in families of various
syndromes, Hudson et al., 2003. Seing multiple
family members with CFS should not surprise paediatricians, crawley.smith07.txt. A genetic background is also
implicated from a study on hypermobility, nijs.etal04.txt,
nijs.etal04.pdf and nijs.etal06.txt.
Genetic
connective tissue disorder Ehlers-Danlos syndrome is associated with
FM, Rowe et al., 1999, and genetic
connective disorder hypermobile joints is correlated with juvenile
CFS, Barron et al., 2001. Family findings consistent with
the hypothesis that CFS represents a deregulation of the endocrine system, torres-harding.etal05.txt,
torres-harding.etal05.pdf. Unrelated household members have even
higher risks of CFS, underhill.ogorman06.txt. Family History of FM
FM family history suggests
genetic implication, arnold.etal04.txt. The mode of inheritance in FM
is unknown, but it is most probably polygenic, buskila.etal07.txt.
There may be a genetic profile
specific for chronic pain states, buskila07.txt. A
study of catechol-o-methyl transferase (COMT) gene haplotypes in Mexican and
Spaniard patients with FM, vargas-alarcon.etal07.txt. Twin Registry
Co-morbidity in twins, Aaron et al., 2001, and a genetic link
behind chronic fatigue,
Buchwald et al., 2001. Fatigue in the general population studied in
twins, Sullivan et al., 2003. Using biometrical structural equation twin
modeling to examine genetic and environmental influences on fatigue, schur.etal07.txt CFS and anxiety are linked in complex manners
without a clear pattern,
Roy-Byrne et al., 2002. Immune factors linked to CFS, Sabath et al., 2002,. Fatigue have a
dramatic effect on functioning in twins discordant for fatigue, Herrell et al., 2002. Chronic
widespread pain affected general health in twins discordant for pain, Aaron et al., 2002. Studies on cognitive processing in twins discordant
for CFS pointed toward a shared genetic trait related to information
processing, mahurin.etal04.txt, mahurin.etal.04.txt,
mahurin.etal04.pdf. Cold pressor pain
sensitivity in twins discordant, ullrich.etal07.txt,
ullrich.etal07.pdf. Sweden also has a twin registry. CFS appears to be a
complex trait resulting from both environmental and genetic sources of
variation without pronounced differences by gender, sullivan.etal.05.txt, sullivan.etal.05.pdf. Genetic Profiles
NIH on the use of blood cell
genetic profiles in CFS,
Vernon et al., 2002. Data from
the Wichita study were used by the CDC to make genetic profiles of patients,
giving support to the theory of CFS subgroups, whistler.etal03.txt,
whistler.etal03.pdf. Genes and exercise intolerance in CFS, whistler.etal05.txt, whistler.etal05.pdf. Differential-display PCR of
peripheral blood for biomarker discovery in CFS, steinau.etal04.txt,
steinau.etal.04.txt. Researchers in Scotland
have developed a genetic test, gene.test.UK06.txt. Transcriptome
analysis of peripheral blood mononuclear cells in CFS subtypes, grans.etal07.txt, grans.etal.07.txt,
grans.etal07.pdf. Genes studied CFS & FM
The 5-HT receptor gene
polymorphism is unrelated to the etiology of FM, Gursoy et al., 2001, Gursoy, 2002, and Gursoy et al., 2003. Serotonin receptor subunit genes HTR3A and
HTR3B analyzed for sequence variations in FM, frank.etal04.txt,
and tander.etal07.txt. CFS patients were characterized
by disturbed serotonin receptor genotypes, narita.etal03.txt, narita.etal03.pdf. Family members with CFS have a genetic mutation
disturbing cortisol metabolism (and the HPA-axis), Torpy, 2000. Association between CFS and the
corticosteroid-binding globulin gene ALA SER224 polymorphism, torpy.etal04.txt,
torpy.etal04.pdf. Genes encoding for proteins in activated leucocytes
have supported the theory of discrete immune disturbances in CFS, powell.etal03.txt, powell.etal03.pdf.
Genetic defects in the GW veterans with CFS analyzed
for mutations in AMPD1, DCP1, and CPT2 genes, press.vladutiu04.txt, vladutiu.natelson04.txt,
vladutiu.natelson04.pdf. Gene expression imbalance suggests T cell activation
and perturbation of neuronal and mitochondrial function, kaushik.etal05.txt, kaushik.etal05.pdf. Gene expression profiling
in CFS, grans.etal05.txt,
grans.etal05.pdf. Reduced levels of estrogen receptor {beta}
mRNA in Swedish patients with CFS, grans.etal06.txt,
grans.etal06.pdf. Australian research: Gene expression correlates with
postinfective fatigue syndrome after infectious mononucleosis, cameron.etal07.txt, cameron.etal.07.txt, cameron.etal07.pdf, press.cameron.etal07.txt.
Pharmacogenomics on CFS and genetics, carmel.etal06.txt,
craddock.etal06.txt, fang.etal06.txt,
fostel.etal06.txt, goertzel.etal06.txt, goertzel.etal06.pdf, goertzel.etal.06.txt, gurbaxani.etal06.txt, maloney.etal06.txt, smith.etal06.txt,
vernon.reeves06.txt, vernon.reeves.06.txt, vollmer-conna.etal06.txt, vollmer-conna.etal.06.txt, whistler.etal06.txt, whistler.etal06.pdf, witkowski06.txt.
This issue was widely broadcasted and discussed in the media, editorial.genes06.txt, editorial.genes.06.txt. HLA Types
HLA
subtype HLA-DQ1 antigen increased in patients with CFS, schacterle.etal04.txt, schacterle.etal04.pdf. Another study also found CFS associated
with HLA-DQA1*01, smith.etal05.txt, smith.etal05.pdf. Mitochondrial DNA
Mitochondrial dysfunction associated with
post-infective fatigue after acute infection with Epstein Barr Virus, vernon.etal06.txt, vernon.etal06.pdf. |
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