Gene Expression Subtypes in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (Figures, Table 3)


Table 3. Top gene networks associated with the chronic fatigue syndrome/myalgic
        encephalomyelitis (CFS/ME) signature, according to Ingenuity Pathways
        Analysis.
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Network^a                             No. of   Score  Gene symbol
                                     genes    ^b
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Hematological disease, cell           17       33     CD47, CRK, CXCR4, GNAS,
 development, hematological                          HIF1A, IFNAR1, IL10RA,
 system development and function                     IL6R, IL6ST, IL7R, JAK1,
                                                     PIK3R1, PKN11, POLR2G,
                                                     PRKAA1, SOS1, TNFRSF1A
Cell morphology, gene expression,     17       21     AKAP10, APP, BRMS1, CITED2,
 cellular assembly and organization                  CREBBP, ETS1, GABPA, GSN,
                                                     GTF2A2, MAPK9, MSN, NFKB1,
                                                     PRKAR1A, SNAP23, SORL1,
                                                     TCF3, UBTF
Protein synthesis, cell cycle,        12       21     ACTR3, ARPC5, CD2BP2,
 gene expression                                     EIF3S10, EIF4G1, EIF4G3,
                                                     FNTA, GLTSCR2, PAPOLA,
                                                     PDCD6, PPP2R5C, TAF11
Gene expression, cellular development, 9       14     ARL4C, BCOR, CEP350, CTBP1,
 hematological system development                    EGR3, NHLH1, NR1D2, PNPLA6,
 and function                                        SELENBP1
Cell cycle, protein degradation,       6        9     ANAPC5, ANAPC11, EBI2,
 protein synthesis                                   EIF2B4, GCN1L1, PDCD2
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a See figure 2.
b Indicates significance of the network in terms of overrepresentation of
 network-eligible genes.