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C F S
- Information International Hypotheses on the cause of CFS/
FM
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The Brain as the target for autoimmune dysfunction
The autonomic nervous system is affected in CFS and
FM as documented in numerous studies. A particular
dysautonomia in CFS is proposed, naschitz.etal04.txt,
naschitz.etal04.pdf. An interesting hypothesis suggests the presence of
autoantibodies against endogenous vasoactive peptides, is FM an autoimmune
disorder?, staines.04.txt. Do vasoactive
neuropeptides and heat shock proteins mediate fatigue-related autoimmune
disorders? staines05.txt, staines05.pdf.
Do cytosine guanine dinucleotide (CpG) fragments induce vasoactive
neuropeptide mediated fatigue-related autoimmune disorders? staines.05.txt, staines.05.pdf.
Chronic ACTH autoantibodies as the cause of
CFS, wheatland05.txt. The Hippocampus is the center of a hypothesis
on FM, wood.04.txt
and wood04.txt. The question of blood-brain
barrier permeability in CFS,
Bested et al., 2001. The astrocytes as primary targets of
pathology in CFS/FM, astrocyte.hypothesis07.txt. An attempt to combine all current knowledge into a
hypothesis, shor03.pdf. Altered neuronal-glial signaling in
glutamatergic transmission as a unifying mechanism in chronic pain and mental
fatigue, hansson.ronnback04.txt. Activation of diencephalic
mast cells by stress, theoharides.etal05.pdf. Common Virus Involved ?
Is
CFS caused by a rare brain infection of a common, normally benign virus, grinde08.txt, grinde.08.txt,
grinde08.pdf. Etiology of FM: The possible role of infection and
vaccination, buskila.etal08.txt. Toxic Agents Involved ?
Are syndromes in environmental medicine variants of
somatoform disorders? wiesmuller.etal03.txt,
wiesmuller.etal03.pdf. Low Blood Volume - Low Oxygen
One theory holds low blood
volume causing low oxygen consumption, to be involved in the cause of CFS/ME
symptoms,
Farquhar et al., 2002. A
trial with hyperbaric oxygen therapy for symptom relief has taken place in There is no basis for the
earlier proposed hypothesis of platelet activation causing hypercoagulation, kennedy.etal06.txt, kennedy.etal06.pdf.
Metabolic Disturbances
Long-chain
polyunsaturated fatty acids in the pathophysiology of CFS, puri.06.txt,
puri06.txt, puri.06.pdf. Metabolic disturbances
including aminoacid, fatty acid and sterol derangements, Dunstan et al., 2000, Dunstan et al., 2000. Deranged fatty acids in erythrocyte
membranes, liu.etal03.txt liu.etal03.pdf . Supplements containing the amino
acids valine, leucine and isoleucine could help, [in accordance
with the muscle energy depletion hypothesis], van West & Maes, 2001. beta-Alanine
and gamma-aminobutyric acid in CFS, hannestad.etal06.txt,
hannestad.etal.06.txt, hannestad.etal06.pdf. Tryptophan metabolism in FM, Schwartz et al., 2003. and schwarz.etal04.txt. Being so important for brain serotonin,
serum tryptophan concentration and availability to the brain in patients with
CFS are studied, badawy.etal05.txt, badawy.etal05.pdf. One study suggests lactic
acid bacteria to be helpful,
Logan et al., 2003
Logan et al., 2003 (pdf). A
finding of abnormal pattern of urine metabolites in CFS/ FM patients, casado.etal04.txt, casado.etal04.pdf. Carnitine metabolism is not disturbed
in CFS, jones.etal05.txt, jones.etal05.pdf. The same researchers analyzed
for CFSUM1, a partially derivatised pyroglutamic acid and CFSUM2, a partially
derivatised serine, and did not find these “markers” present in
ME/CFS. However they found some evidence in patients for underlying
inflammatory disease and for reduced intramuscular collagen, jones.etal.05.txt, jones.etal.05.pdf.
Other authors found CFSUM1 and CFSUM2 to be methodological artifacts, chalmers.etal05.txt, chalmers.etal05.pdf. Inflammation
When alpha1-antitrypsin deficiency is treated FM symptoms improve, blanco.etal05.txt. Hypocortisolism
The development, mechanisms and consequences of hypocortisolism on different bodily systems, fries.etal05.txt, fries.etal05.pdf. |
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