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C F S
- Information International Hypothesis:
Oxidative Stress
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Oxidative
Stress
Enzyme deficiency cause 'oxidative stress' in CFS, a suggestion
raised some years ago, richards.etal00.txt, keenoy.etal01.txt, keenoy.etal01.pdf. Oxidative stress
might reduce essential fatty acids in erythrocyte membranes of CFS patients, nijs.demeirleir04.txt, nijs.demeirleir04.pdf. Oxidative stress on erythrocyte maturation implies immature
cells (stomatocytes), richards.etal07.txt, richards.etal07.pdf.
Oxidative stress has also been suggested as the cause of FM, galeotti.etal01.txt. The increased pentosidine levels in FM blood is also an indicator of oxidative stress, hein.franke02.txt. More evidence to link FM with disturbance in the oxidant/anti-oxidant system, bagis.etal03.txt. Researchers in Scotland correlated the
‘gold standard’ measure of in vivo oxidative stress
(isoprostanes) with symptoms in CFS, kennedy.etal05.txt, kennedy.etal05.pdf. Increased oxidative stress
suggested by low serum vitamin E concentrations in patients with CFS, miwa.fujita08.txt, miwa.fujita08.pdf. Treating Chronic Fatigue states as a disease of the regulation of
energy metabolism, bains08.txt, bains.08.txt, bains08.pdf. Lower serum zinc in CFS: Relationships to immune dysfunctions and relevance for the oxidative stress status in CFS, maes.etal05.txt, maes.etal05.pdf. Decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum Zinc and defects in T cell activation, maes.etal06.txt. An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in (CFS) and major depression: Evidence that nitrosative stress is another factor, maes.etal08.txt.
Antioxidant
status, lipid peroxidation and NO in fibromyalgia: etiologic and therapeutic
concerns, ozgocmen.etal05.txt. Current
concepts in the pathophysiology of fibromyalgia: the potential role of
oxidative stress and nitric oxide, ozgocmen.etal.05.txt. Calcium
Channel Disturbance
Disturbances in ion channel functioning has been hypothesized, chaudhuri.etal00.txt. An Italian paper studied intracellular Ca
and Mg in FM, magaldi.etal00.txt. Disturbances of NO Metabolism
Dr. Marty Pall has published multiple
papers suggesting NO metabolism as the cause of CFS and other syndromes,
summed in his book, pall06.book.txt. Nitric
oxide synthase partial uncoupling as a key switching mechanism for the
NO/ONOO- cycle, pall07.txt, pall07.pdf.
His latest contribution: Post-radiation
syndrome as a NO/ONOO(-) cycle, CFS-like disease, pall08.txt,
pall.08.txt, pall08.pdf. Elevated
protein carbonyls, smirnova.pall03.txt. NO can be produced in minute quantities during passive exercise,
which may relieve symptoms in FM and CFS, sackner.etal04.txt, sackner.etal04.pdf. Does NO trigger central sensitization? nijs.etal05.txt, nijs.etal05.pdf. Antiviral pathway deregulation of CFS induces NO production in
immune cells that precludes a resolution of the inflammatory response, fremont.etal06.txt.
No association
between the Glu298Asp polymorphism of the endothelial NO-synthase gene and
FM, alasehirli.etal06.txt. Belgian researchers: Not in the mind of
neurasthenic lazybones but in the cell nucleus: patients with CFS have
increased production of nuclear factor
kappa beta, maes.etal.07.txt, Not in the mind
but in the cell: increased production of cyclo-oxygenase-2 and inducible NO
synthase in CFS, maes.etal07.txt. |
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