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C F S
- Information International Immunology
and CFS/ FM
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Reviews on Immunology in CFS and FM
Recent
review: lorusso.etal08.txt, lorusso.etal.08.txt, lorusso.etal08.pdf. Earlier by the New Jersey
group, Natelson et al., 2002, natelson.etal02.pdf. Status
of immune mediators in FM, gur.oktayoglu08.txt. Correlation with CFS/ FM Illness
Correlation between immunologic
measures and severity of CFS illness,
Cruess et al., 2000. These researchers related Paul-Bunnell
antibodies in disease states with immune functioning, Patarca-Montero & Fletcher,
2002. Only few immunology
parameters of importance for understanding the immune dysfunction in
CFS,
Hanson et al., 2001. Bronchial hyper reactivity
unrelated to the immune cell derangements in CFS patients, Nijs et al., 2003, Nijs et al., 2003 (pdf). Cellular and
humoral immune abnormalities in Gulf war veterans 2– 8 years after the
war, vojdani.thrasher04.txt, vojdani.thrasher.04.txt, vojdani.thrasher04.pdf. Are anti-polymer antibodies correlated
with pain and fatigue severity in patients
with FM?, sarzi-puttini.etal07.txt. Immune Cells tested
FM women did not have lower NK
cell activity than controls, landis.etal04.txt.
NK cell functions could be
affected differently in different CFS clusters, Stewart et al., 2003, Stewart et al., 2003 (pdf). Diminished intracellular perforin was
suggested to be the cause of NK cell malfunction, maher.etal05.txt,
maher.etal05.pdf. Review on cytolytic cells in
CFS, Patarca-Montero, 2002. Increased neutrophil apoptosis (cell death) was
found in CFS, kennedy.etal04.txt, kennedy.etal.04.txt, kennedy.etal04.pdf. FM patients had
significantly higher norepinephrine and anandamide plasma levels. Neutrophils of FM patients showed an elevated
spontaneous H(2)O(2) production. The ability of neutrophils to adhere was
negatively correlated with serum cortisol levels. Adhesion and phagocytosis
capabilities of neutrophils correlated positively with anandamide plasma
levels, kaufmann.etal08.txt. Lymphocyte subset differences
in patients with CFS, multiple sclerosis and major depression, robertson.etal05.txt. CFS monocytes have decreased beta-endorphin
amount, Panerai et al., 2002, A test for
eosinophil cell activation (cationic protein X) demonstrated increased
concentration in CFS patients,
Schacterle et al., 2001. Adhesion molecules and cytokine
expression in FM: Increased L-selectin
on monocytes and neutrophils, macedo.etal07.txt.
Decreased
expression of CD69 in CFS in relation to inflammatory markers: evidence for a
severe disorder in the early activation of T lymphocytes and natural killer
cells, mihaylova.etal07.txt. Immune Factors in Spinal Fluid
Analyzed spinal fluid in CFS, natelson.etal05.txt, natelson.etal05.pdf. Immune Modulation/ Altered Immune Function
Immunomodulation may benefit
CFS patients,
Klimas et al., 2001 (abstract), Klimas et al., 2001 (pdf). Early results from immunotherapy, Patarca-Montero et al., 2001 (abstract), Patarca-Montero et al., 2001 (pdf). The current model of CFS used in In Sweden trials with Staphylococcus toxoid for
FM/CFS has been successfully accomplished, but maintenance therapy is
needed,
Zachrisson et al., 2002. Further evidence for effect includes
antibody response with some patients but not with others, zachrisson.etal04.txt, zachrisson.etal04.pdf. One-year follow-up on this project, gottfries.etal06.txt. Prolonged illness after infectious mononucleosis is associated
with altered immunity but not with increased viral load, cameron.etal06.txt, cameron.etal06.pdf. Vaccination may play a role in CFS, appel.etal07.txt, appel.etal07.pdf.
Immunology and Sleep / Pregnancy
Immunology in relation to
psychology and sleep, Van Hoof et al., 2002, and Van Hoof et al., 2002. The occurrence of pregnancy
does not improve CFS nor does it worsen symptoms, schacterle.komaroff04.txt, schacterle.komaroff04.pdf.
Immunology and Exercise
Complement-activation after
exercise in CFS patients, sorensen.etal03.txt,
sorensen.etal03.pdf. Intracellular immune deregulations as the
cause of exercise intolerance in CFS, nijs.etal04.txt,
and a commercial study ‘implicate abnormal immune activity in the
pathology of exercise intolerance in CFS and are consistent with a channelopathy
involving oxidative stress and nitric oxide-related toxicity’, snell.etal05.txt. Antibodies in CFS/ FM
Anti-nuclear envelope
antibodies present in autoimmune diseases and in CFS, Nesher et al., 2001.
Auto-antibodies in CFS,
Nishikai et al., 2001 (short), Nishikai et al., 2001 (full paper). Slightly higher levels of
anti-polymere-antibodies were found in FM, jensen.etal04.txt.
In FM the finding of ANA (anti-nuclear antibodies) is of no
significance,
Al-Allaf et al., 2002. CFS had
higher rates of antibodies to microtubule-associated protein 2 (MAP2), vernon.reeves05.txt, vernon.reeves.05.txt. Low
antibody markers of elastin synthesis in patients with FM, keith.etal06.txt. Antibodies to Herpes Simplex 1
and 2, bond.dinan06.txt. IgM antibody against HCMV in a subpopulation of CFS
patients, Lerner et al., 2002. Also with Epstein-Barr virus, Lerner’s
research found IgM antibodies in a subset of CFS, lerner.etal04.txt,
lerner.etal04.pdf. Autoantibodies against thyroid tissue in FM, ribeiro.proietti04.txt, pamuk.cakir06.txt and bazzichi.etal.07.txt. Increased serum IgA and IgM
against LPS of enterobacteria in CFS, maes.etal06.txt,
maes.etal06.pdf. IgM-related
immune response directed against neopitopes formed by oxidative or
nitrosative damage to lipids and proteins, maes.etal.06.txt.
Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in
CFS and major depression: evidence that an IgM-mediated immune response against
Pi is one factor underpinning the comorbidity, maes.etal.07.txt. |
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