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C F S
- Information International ATP
– Mitochondria - Metabolism
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Disturbance
of Mitochondrial functioning
Loss of mitochondrial activity is
characteristic in ageing and in fatigue states, and is has been suggested
that nutritional supplements may help, agadjanyan.etal03.txt.
Medications have now emerged as a
major cause of mitochondrial damage, which may explain many adverse effects, neustadt.pieczenik08.txt. A study on muscle fibres in FM found low numbers of mitochondrias, and evidence of DNA fragmentation, sprott.etal04.txt. The Glasgow team using magnetic resonance spectroscopy, 31-P MRS on muscles, is open to this cause for CFS symptoms, chaudhuri.behan04.txt, chaudhuri.behan04.pdf. Calculation of free Mg2+ levels from previous data showed CFS patients had higher resting free Mg2+ levels compared to sedentary controls, mccully.etal06.txt More evidence is accumulating in relation
to mitochondrial dysfunctioning as the cause of most (if not all) chronic
diseases, letter.fiddian-green04.txt. Use of phosphocreatine kinetics to
determine the influence of creatine on muscle mitochondrial respiration in
vivo, smith.etal04.txt, smith.etal04.pdf.
Acute phase phospholipids
related to the cardiolipin of mitochondria in the sera of patients with
chronic fatigue syndrome (CFS), hokama.etal08.txt,
hokama.etal08.pdf. Significant lower
ATP
levels were observed inside platelets of FM patients vs. healthy controls, bazzichi.etal08.txt. One hypothesis suggests the presence of
autoantibodies against endogenous vasoactive peptides, staines04.txt,
staines04.pdf. Are vasoactive neuropeptide autoimmune
fatigue-related disorders mediated via G protein-coupled receptors? staines_05.pdf. Does dysregulation of key
epigenetic and biochemical pathways occur in postulated vasoactive
neuropeptide autoimmune disorders? staines.5.txt,
staines.5.pdf. Do vasoactive neuropeptide
autoimmune disorders explain pyridostigmine's association with Gulf War
syndrome? staines_5.txt. Therapeutic and
preventive interventions for postulated vasoactive neuropeptide autoimmune
fatigue-related disorders, staines5.txt, staines5.pdf. The
suggestion that enzyme deficiency in CFS cause 'oxidative stress' was raised some years ago, fulle.etal00.txt,
fulle.etal.00.txt. Modification of the
functional capacity of sarcoplasmic reticulum membranes, fulle.etal03.txt, fulle.etal03.pdf.
Specific correlations between muscle oxidative
stress and CFS: a working hypothesis, fulle.etal08.txt,
fulle.etal08.pdf. Hypothesis: CFS is caused by dysregulation of hydrogen sulfide (HS) metabolism,
due to reduction in the capacity of mitochondria to utilize oxygen and
synthesize ATP, lemle08.txt. A possible link to deregulation of the RNaseL pathway, cluding problems with RNase L cleavage, nijs.etal03.txt, nijs.etal03.pdf. Also combining current knowledge on immune deregulation, RNAse disturbance and NO production presents a hypothesis, nijs.etal04.txt, nijs.etal04.pdf. |
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